The invention of the cholera vaccine.

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Cholera is an infection of the small intestine caused by some strains of the bacterium Vibrio cholerae.


The Spanish bacteriologist Jaime Ferrán i Clúa invented the cholera vaccine in 1885 by using the following method:

  • First, a sample of the bacteria was mixed with broth in a flask.
  • The culture (growth of bacteria in nutrient media) was completed after 6 hours at 37 degrees Celsius.
  • Once the mixture became cloudy, it was ready to be injected as a vaccine

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Microscopic photograph of Vibrio cholerae:




Here is a photograph of Jaime Ferrán i Clúa:

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