Histologic staining is the artificial colouration of a substance to facilitate examination of tissues, microorganisms or other cells under the microscope.
The Italian physician Alfonso Giacomo Gaspare Corti invented the process of histologic staining in 1851 while trying to observe the vestibulocochlear nerves of the cochlea (part of the inner ear involved in hearing) in their fresh state. He first preserved them for a few hours in a saturated solution of sodium chloride and then stained them with carmine (a reddish pigment) which then allowed him to see the sheaths of the nerves with clarity. Here is a photomicrograph of a flatworm (Pseudorhabdosynochus morrhua) stained with carmine:
[ux_image_box img=”1523″ image_width=”30″ link=”https://en.wikipedia.org/wiki/Pseudorhabdosynochus_morrhua” target=”_blank”]
Here is a portrait of Alfonso Corti:
[ux_image_box img=”1526″ image_width=”40″ link=”https://wellcomecollection.org/works/ebs37ax3?wellcomeImagesUrl=/indexplus/image/L0015264.html” target=”_blank”]
- https://medical-dictionary.thefreedictionary.com/Histologic+ staining
- https://archive.org/stream/b2234410x?ref=oI#mode/2up ?ref=oI, pages 22-23.
- https://en.wikipedia.org/wiki/Pseudorhabdosynochus_ morrhua
- https://wellcomecollection.org/works/ebs37ax3?wellcome ImagesUrl=/indexplus/image/L0015264.html