Fibrinogen

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Table of Contents
DEFINITION

Fibrinogen is a protein in the blood plasma that is essential for the coagulation of blood and is converted to fibrin by the action of thrombin in the presence of ionised calcium[1]. It is also called “coagulation factor I”.

DISCOVERY

The Swedish physiologist Olof Hammarsten discovered[2] fibrinogen in 1877 after researching what substances in the blood cause it to coagulate. In his 1877 publication, he notes the method he used to isolate fibrinogen:

  • He first separated the plasma from horse blood and mixed it with sodium chloride after which a precipitate was formed.
  • This precipitate was then dissolved in a 6-8% solution of sodium chloride causing a precipitate to be formed again. This step was repeated a few times until an insoluble precipitate (fibrinogen) was formed.
DISCOVERER

Here is a photograph[3] of Olof Hammarsten:

1841-1932